A glycoprotein made out of 237 mostly hydrophylic amino acids is composed of two subunits alpha (92 amino acids) and beta (145 amino acids), that together create a hydrophobic core with high surface to volume ratio. Pregnyl HCG can be extracted from urine of pregnant women or through recombinant DNA technology with genetically modified microbes. The end product is freeze dried with nitrogen gas and buffered with monobasic and dibasic sodium phosphate. To adjust the pH values hydrochloric acid or sodium hydroxide may be used. As the end product it is presented with accompanying bacteriostatic water for dilution prior to injecting.
This hormone is naturally produced by the fertilized egg to form the placenta, because of this fact it is used in pregnancy tests. When present it is a sure sign of pregnancy and if you want to test if the hcg you ordered is real buy a fertility test and use it, if it shows you are pregnant your pregnyl hcg is original. While hcg is not found in the male body, the luteinizing hormone that is it’s analog is however produced by the pituitary gland of all humans throughout their life.
Human chorionic gonadotropin is used primarily in fertility medicine for both men and women. In females it is an ovulation inducer very effective in activating egg release and starting ovulation. With males it is used as daily injections to speed up the lowering of the eggs into the scrotum in children before puberty while in adult males, it is used to increase the sperm count, again as a part of fertility treatment. The third, though off prescription use of hcg is for weight loss as instructed by dr. Simeons and recently popularized by Kevin Trudeau, Dr. Oz. and Oprah as well as many known performance artists that have testified to loosing post baby fat or loosing stubborn weight only after they tried the hcg protocol. The hcg diet itself is not new, it has been around for over 60 years and was first introduced by dr. Simeons in the 1950’s, unprecedented weight loss that was achieved in almost all subjects was only used in Italy. The so called dr. Simeons hcg protocol was again used in the 1970’s by a limited number in the USA, but it’s recent use and wide media attention has put Pregnly hcg diet at the top spot in obesity treatment as it has proven to boost metabolism without exercise, making long term fat loss a possibility for the first time. Because dr. Simeons hcg protocol is targeting long term fat deposits and achieving decrease in overall body fat as well as fat redistribution it shows promise in the ongoing battle against obesity epidemic in the developed world.
Brand names include: Ovidrel, Chorigon, Choron, APL, Gonic, Novarel, Chorex, Pregnyl, Profasi, Corion, Fertigyn, Follutein, Eurtrig, Lupi, Silfasi, Proficient and many others. They all contain human chorionic gonadotropin in different strengths: 500, 1000, 1500, 2500, 5000 or 10 000 international units ( i.u. or u.i. for short) and are only available in the form of injectable solution. HCG drops, pellets pills or «homeopatic» preparations do not contain the active ingredient human chorionic gonadotropin and therefore do not work.
Laboratory should establish the degree of cross reactivity in radio immunoassay, because hcg can cross react, especially in gonadotropins like lutenising hormone.
Pregnyl HCG is injected in the subcutaneous fat deposits under the skin with 28 or similar gauge needle, much the same as the one used for diabetes injections. When used for boys before puberty to lower the testis into the scrotum the injection is performed into muscle tissue usually in the buttocks area as it has the least amount of blood vessels and nerves. Procedure can easily be thought, so that the subject can administer the pregnyl hcg injection in the comfort of his own home. Do not inject yourself with hcg unless you are properly trained and know the correct procedure. Only use a new clean syringe and needle and properly dispose of them immediately after the procedure in a way that it is unreachable to kids or pets.
Pregnyl side effects
If you notice any signs of an allergic reaction like: rash, shortness of breath, swelling of your throat, lips, tongue or face, stop the use and contact your doctor or emergency immediately.
Should you notice any of the signs of a blood clot, such as tingling in your extremities, headache, dizziness and/or confusion, warmth, numbness or pain, contact your doctor immediately.
Should you notice any of the signs of ovarian hyper stimulation syndrome: diarrhea or nausea, increase urination, pain in the pelvis area or stomach, swelling or short breath, contact your doctor immediately.
Should you notice any of the signs of early puberty: deepening of the voice, growth of bodily hair, acne or increased sweating, contact your doctor immediately.
Should you notice any irritation, redness or itching of the injection spot, contact your doctor immediately.
Should you notice depression, weight gain or tenderness in the nipple are, contact your doctor immediately.
When using hcg the possibility of having twins, triplets or even quadruplets soars, as they fall into the category of higher risk pregnancies discuss it with your doctor.
Pregnyl side effects that may or may not occur are: migraines, fatigue, edema, sensitivity, rash, gynecomastia, early puberty, depression, arterial thromboembolism.
IMPORTANT: Do not use Pregnyl if you are already pregnant as it can harm the forming baby! It is not known if human chorionic gonadotropin passes into milk. If you become pregnant during HCG use, stop use and discuss it with your doctor immediately. Do not use pregnyl hcg if you are allergic to this medicine or any of it’s ingredients or if you have androgen related tumors like that of the prostate or male breast.
Pregnyl should not be used if you have hormone related tumors, ovarian cysts, or kidney disease, asthma, are allergic to any of the ingredients of this medication, have thyroid or adrenal disorder or have already reached early puberty.
In the case of any of the aforementioned conditions you must consult a doctor as with knowing your previous medical history he will be able to decide weather you can use hcg at all and also make dose adjustments, if needed.
Do regular doctors check ups to ensure you are in good health for the duration of use. Do not begin, stop or change the dosage without consultation with your doctor. Always use Pregnyl as prescribed by your doctor, never use higher dosages or use it for longer than it is recommended and do read the insert of your medication prior to use.
Most HCG brands come in two separate ampoules, one with liquid and another with powder containing active ingredient, the liquid ( water and preservative ) is drawn into the syringe, injected into the ampoule with powder, mixed until completely dissolved, drawn back in the syringe, the needle is changed for a fresh one prior to injecting, the possible air bubbles must be dispensed off, then the liquid is injected. Should you notice a change in color or particles do not inject the solution. After the mix has been made it has to be refrigerated at all times and used within 40 days.
Keep pregnyl in a dry, dark and cold container out of the reach of children. HCG once mixed must be refrigerated at all times and used (depending on the brand) within 40-60 days. Should any change in color occur or visible particles have formed, do not use the mixture and dispose of it immediately.
If you miss a dose of pregnyl
Inject as soon as you can and proceed in same order as before, if are close to the time of your next injection, do not double dose.
Possible overdose of pregnyl HCG
Life threatening symptoms are not expected, should overdose occur contact your doctor.
Interaction with other drugs:
Prior to use inform your doctor of any medications, even otc, including vitamins, minerals or herbal concoctions. Antagon, Follistim – ganirelix a follicle stimulating medication is known to interact with hcg.